Cohorts
| Aarhus Osteoporosis Study (AROS) | DNK | Aarhus |
| Case-control study (n=801). |
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Working groups: FN/LS BMD (GEFOS2) |
| Aberdeen Prospective Osteoporosis Screening Study (APOSS) | GBR | Aberdeen |
| APOSS is a longitudinal population-based study of osteoporotic fracture risk assessment in Caucasian women aged 45-54 years of age at baseline (n=3,268). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Anglo-Australasian Osteoporosis Genetics Consortium - Geelong Osteoporosis Study (AOGC-GOS) | AUS | Geelong |
| Population-based BMD cohort (from electoral rolls) and case-control for fracture cases; all drawn from Geelong general population of men and women (n=2,922). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Vertebral |
| Anglo-Australasian Osteoporosis Genetics Consortium - Sheffield (AOGC-SHEFFIELD) | GBR | Sheffield |
| Large population-based cohort of community-dwelling elderly women aged ≥ 75 years (n=4,014). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Vertebral |
| Austrios A (AUSTRIOS-A) | AUT | Graz |
| A population based study of men and women with and without osteoporosis (n=893). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Austrios B (AUSTRIOS-B) | AUT | Graz |
| 95 nursing homes in Austria, patients had to be relatively healthy (n=1,158). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Barcelona Cohorte Osteoporosis (BARCOS) | ESP | Barcelona |
| A cohort study of unrelated women aged 44 years and over that were recruited from the Menopausal Unit of the Hospital del Mar, Barcelona. All of the participants were consecutive, unselected, postmenopausal women who had presented to the outpatient clinic for a baseline visit due to menopause (n=1,400). |
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Working groups: FN/LS BMD (GEFOS2) |
| Calcium Intake Fracture Outcome Study (CAIFOS) | AUS | Perth |
| During 1998, 1,500 women were recruited to study whether a daily calcium supplement for 5 years helps to prevent fractures compared to a diet without a supplement. The main outcome of the study is to determine whether calcium is useful as a supplement to prevent osteoporotic fracture in elderly women (n=1,347). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Calex-Family Study (CALEX) | FIN | Jyväskylä |
| A family-based study to study Fractures in Puberty - Causes and Implications in Old Age (n=994) |
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Working groups: FN/LS BMD (GEFOS2) |
| Canadian Multicentre Osteoporosis Study (CaMos) | CAN | Vancouver, Calgary, Saskatoon, Hamilton, Toronto, Kingston, Québec City, Halifax, St John's |
| A population-based, randomly selected, prospective cohort study from 9 Canadian cities followed for 14 years for osteoporosis-related traits and outcomes (n=2,388). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Cantabria Osteoporosis Case-control (CABRIO-CC) | ESP | Santander |
| Clinic-based study of control individuals and patients with osteoporosis living in Cantabria, a region in Northern Spain (n=2,321). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Vertebral |
| Cantabria-Camargo (CABRIO-C) | ESP | Santander |
| A community-based study designed to evaluate the prevalence of metabolic bone diseases in postmenopausal women and men older than 50 attended at a primary care center in Northern Spain (n=1,450). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Vertebral |
| Chinese Community Elderly Men and Women Cohorts (HK) | CHN | Hong Kong |
| Two thousand Chinese men and women living in the community, aged 65 years and above, were recruited by posting public advertisements at community centers for the elderly and housing estates in Hong Kong since 2001 (n=3,872). |
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Working groups: FN/LS BMD (GEFOS2) |
| Danish Osteoporosis Prevention Study (DOPS) | DNK | Aarhus, Odense, Cope |
| Population-based study of perimenopausal women. The women were followed for 10 years. Approximately 35% were treated with Hormone Replace Therapy (n=1,716). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| deCODE Genetics Replication (deCODErep) | ISL | Reykjavik |
| The study includes 40,000 individuals taking part in various disease projects (n=3,138 with Fx/DXA assesment and DNA samples) |
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Working groups: FN/LS BMD (GEFOS2) |
| Early risk identification and effective prevention of osteoporosis based bone fractures in Polish population (EPOLOS) | POL | Warsaw, Lodz, Poznan, Krakow, Wroclaw, Bydgoszcz |
| The EPOLOS Study is a population-based, cross-sectional study of unrelated men and women aged 19-81 years, initiated to identify early risk and effective prevention of osteoporosis based bone fractures in Polish population (n=715). |
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Working groups: FN/LS BMD (GEFOS2) |
| Edinburgh Osteoporosis Study (EDOS) | GBR | Edinburgh and Lothian |
| Clinical referral population of patients assessed for evaluation of osteoporosis (n=2,024). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| European Prospective Osteoporosis Study (EPOS) | EUROPE | 18 centres across 13 countries in Europe |
| An extension of the European Vertebral Osteoporosis Study (EVOS), aimed to quantify incidence of vertebral and non-vertebral fractures. EVOS had recruited some 17,342 men and women aged over 50 years from 36 centres in 19 European countries. Each centre had recruited a random sample of up to 300 men and 300 women from population registers stratified into six 5-year age bands: 50-54, ..., 70-74 and 75+. A total of 7,273 participants from 31 EVOS centres took part in the EPOS follow up study (n=2,092 with with Fx/DXA assesment and DNA samples). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Europen Prospective Investigation into Cancer, Norfolk study (EPICNOR) | GBR | Norfolk |
| A random sample of 1,511 men and women in the top decade of age in the 25,000 participant EPIC-Norfolk prospective study were recruited into a bone fragility study with DXA measurements. GWA data were available for 249 participants with BMD measurements who had been entered into a GWAS investigation of obesity (n=1,399 with Fx/DXA assesment and DNA samples). |
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Working groups: FN/LS BMD (GEFOS2) |
| FLORENCE study (FLOS) | ITA | Florence |
| The FLOS Study is a population-based cohort study of unrelated men and women aged 50 years and over, collected to perform genetic studies in osteoporosis (n=1,000). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Geelong Osteoporosis Study (GOS) | AUS | Geelong |
| A major epidemiological study of 1600 females and 1600 males. The results of this study have formed the basis of the Australian National Bone Density Range, defined age and gender specific fracture rates and identified risk factors for osteoporosis and fracture. Is part of the Anglo-Australasian Osteoporosis Genetics Consortium (AOGC) |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Genetic Analysis of Osteoporosis in Greece (GROS) | GRC | Athens |
| A population-based, prospective cohort study of unrelated Greek men and women aged 43 years and over who visited the Department of Orthopaedic Surgery, University Hospital of Thessalia, Larissa, Greece (n=606). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Hertfordshire Cohort Study (HCS) | GBR | Hertfordshire county |
| A population-based cohort study of men and women born between 1931 and 1939 in the county of Hertfordshire, UK. It was initiated to evaluate interactions between the genome, the intrauterine and early postnatal development, and adult diet and lifestyle in the aetiology of chronic disorders in later life (n=2,973). |
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Working groups: FN/LS BMD (GEFOS2) |
| Institute of Biochemistry and Genetics Ufa Scientific Centre RAS (GEVUR) | RUS | Ufa |
| A case-control and population-based, prospective cohort study of unrelated women aged 50 years and over, men with osteoporotic fractures and helthy men (n=999). |
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Working groups: FN/LS BMD (GEFOS2) |
| Korean osteoporosis study at Asan Medical Center (KorAMC) | KOR | Seoul |
| A hospital registered, cross-sectional study of postmenopausal Korean women (n=1,294). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Longitudinal Aging Study Amsterdam (LASA) | NLD | Amsterdam |
| An ongoing multidisciplinary cohort study on predictors and consequences of changes in physical, cognitive, emotional and social functioning in older persons (n=517) |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Manitoba McGill Fracture Study (ManMc) | CAN | Winnipeg |
| A population-based sample of women experiencing a validated clinical hip or forearm fracture requiring surgical intervention (n=1,062). |
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Working groups: FN/LS BMD (GEFOS2) |
| MrOS Sweden (MrOSS) | SWE | Gothenburg, Uppsala and Malmö |
| A multicenter, prospective study including 3,014 elderly men in Sweden, Hong Kong (~2,000), and the United States (~6,000). The MrOS Sweden cohort consist of three sub-cohorts from three different Swedish cities (n=1,005 in Malmö, n=1,010 in Göteborg, and n=999 in Uppsala). Study subjects (men aged 69–80 years) were randomly identified using national population registers, contacted and asked to participate. To be eligible for the study, the subjects had to be able to walk without assistance, provide self-reported data, and sign an informed consent; there were no other exclusion criteria. The study was approved by the ethics committees at the Universities of Gothenburg, Lund, and Uppsala. Informed consent was obtained from all study participants.(n=2,922 with Fx/DXA assesment and DNA) |
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Working groups: DXA/HSA DXA/Lean_Mass FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral pQCT ULTRASOUND/Heel |
| North of Scotland Osteoporosis Study (NOSOS) | GBR | Aberdeen, Dingwall |
| A population-based osteoporosis screening programme of postmenopausal females aged 60-82 years of age at baseline (n=1,293). |
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Working groups: FN/LS BMD (GEFOS2) |
| Odense Androgen Study (OAS) | DNK | Odense |
| Population-based study on Danish men aged 60-74 years. Follow-up on incident clinical fractures (from inclusion until dec 2010). (n=600) |
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Working groups: FN/LS BMD (GEFOS2) |
| Osteoporosis: SNPs To Environment Study (OSTEOS) | GRC | Athens |
| A cross-sectional study of unrelated women, aimed to assess genetic and enrironmental factors, especially nutrition, and their possible interactions on BMD (n=629). |
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Working groups: FN/LS BMD (GEFOS2) |
| Prevalence of osteoporosis in Slovenia (SLO-PREVAL) | SVN | Ljubljana |
| A cross-sectional study where premenopausal women aged between 35-50 years and postmenopausal women and men aged over 50 years were included to perform genotype-phenotype association studies (n=716). |
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Working groups: FN/LS BMD (GEFOS2) |
| Prospective Epidemiological Risk Factor (PERF) | DNK | Copenhagen |
| The Prospective Epidemiological Risk Factor (PERF) Study is based on subjects who were screened for or enrolled into RCT to identify genetic and other risk factors of diseases in the elderly (n=3,973). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |
| Quebec sample (Geos) | CAN | Quebec |
| Population-based sample collected for the sudy of bone mineral variation including only women from 18 to 84 years (n=2,379) |
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Working groups: FN/LS BMD (GEFOS2) |
| Sheffield Study (SHEFFIELD) | GBR | Sheffield |
| A population based study part of the Anglo-Australasian Osteoporosis Genetics Consortium (AOGC) |
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Working groups: FN/LS BMD (GEFOS2) |
| The Age, Gene/Environment Susceptibility Reykjavik Study (AGES) | ISL | Reykjavik |
| Originally comprised a random sample of 30,795 men and women born in 1907-1935 and living in Reykjavik in 1967. A total of 19,381 people attended, resulting in a 71% recruitment rate. The study sample was divided into six groups by birth year and birth date within month. One group was designated for longitudinal follow up and was examined in all stages; another was designated as a control group and was not included in examinations until 1991. Other groups were invited to participate in specific stages of the study. Between 2002 and 2006, the AGES-Reykjavik study re-examined 5,764 survivors of the original cohort who had participated before in the Reykjavik Study. |
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Working groups: FRACTURE/Any_type FRACTURE/Vertebral |
| The Dubbo Osteoporosis Epidemiology Study (DOES) | AUS | Dubbo |
| A cohort study of approximately 2/3rds of the men and women in Dubbo, aged 60 years or older from 1989 every 2 years to the present. Data collected include BMD, life style, medical assessment, medication use and a wide range of health conditions and outcomes. It has been extended recently to include any person older than 20 years (n=1,457). |
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Working groups: FN/LS BMD (GEFOS2) |
| The Umeå Fracture and Osteoporosis Study (UFO-I) | SWE | Umeå |
| A nested case-control study investigating associations between genes, lifestyle and osteoporotic fractures. The study is based on the prosepctive and populationbased Northern Sweden Health and Disease Study cohort, initiated to assess risk factors for diabetes and cardiovascular disesase (n=4,409). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type |
| The Umeå Fracture and Osteoporosis Study - 2 (UFO-2) | SWE | Umeå |
| A nested case-control study investigating associations between genes, lifestyle and osteoporotic fractures. The study is based on the prosepctive and populationbased Northern Sweden Health and Disease Study cohort, initiated to assess risk factors for diabetes and cardiovascular disesase (n=2,022). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type |
| Women's Health Initiative Genetic Components of HIP Fracture (GeCHIP) Consortium - BMD (WHI GeCHIP - BMD) | US | Pittsburgh PA, Birmingham AL, Tucson/Phoenix AZ |
| BMD portion of GeCHIP. This is a subsample of the Women's Health Initiative BMD cohort (n=11,488) . Measurements were made at 3 of 40 US clinical centers (Pittsburgh PA, Birmingham AL, and Tucson/Phoenix AZ). Women (n=4,000) were selected from the WHI BMD cohort with the best/worst hip-Z-score (baseline) and best/worst physical functioning score (last available RAND36) (n=3,923 with DXA assesment and DNA). |
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Working groups: FN/LS BMD (GEFOS2) FRACTURE/Any_type FRACTURE/Vertebral |